Estimation the Importance of Serum Calcium Level Depending on The Effect Index in Coronary Artery Obstruction
Keywords:
Atherosclerosis, calcium score, atherogenic index, oxidized LDL, hyperlipidemiaAbstract
Many researches relied on the importance of treating high cholesterol to prevent heart disease, and taking calcium and its level was not among the therapeutic considerations for the heart, this hypothesis gave an impetus to studying the serum level of calcium and lipid profile in patients who are at risk of atherosclerosis, and is calcium regulation of the same importance as treating lipids, or does the lipids clear of the atherosclerosis risk? One hindered and eighty individuals whose ages were from (40-70 years), they were divided into two groups according to their calcium score, in addition to the healthy group, the work was carried out between October 2022 and December 2022, diagnosis was made by a cardiac specialist in the Ghazi Al-Hariri Hospital for Surgical Specialties. To achieve the purpose of the study serum lipid profile, troponin, oxidized LDL, ionized calcium and atherogenic index were analyzed. Serum TG/HDL ratio in patients with high Ca-score show the highest level (with p ≤ 0.05) when compared with patient have normal Ca-score and healthy subjects, Patient have high Ca-score have lowest serum Ca-ionized level in comparison with the two groups (with p≤ 0.05). those patients have the highest serum level of oxidized LDL and troponin when compared with the two other groups. The nonsignificant difference of the both ratio s. TG/HDL and LDL/HDL between patients have high calcium score and normal calcium score strongly suggests that cardiologists must take serum calcium inning in their treatment.
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Noor N. Nafie, Basil O. Saleh, Sabah M.
Fadhil The role of high sensitive-crp and
pentraxin iii in progression of coronary
artery calcification in patients with
coronary artery disease Vol. 6, Issue, 12,
pp.10407-10412, December, 2014
Al Alwany AA. Effect and benefit of
percutaneous coronary intervention in
chronic total occlusion on ventricular
repolarization: QT correction and dispersion.
J Med Life. 2022 Aug;15(8):1025-1030. doi:
25122/jml-2022-0207. PMID: 36188654;
PMCID: PMC9514816.
Zhao, X., Wang, D., & Qin, L. (2021).
Lipid profile and prognosis in patients with
coronary heart disease: a meta-analysis of
prospective cohort studies. BMC
cardiovascular disorders, 21(1), 1-15.
Park JM, Lee B, Kim YS, Hong KW, Park YC,
Shin DH, Kim Y, Han K, Kim K, Shin J,
Kim M, Kim BT. Calcium Supplementation,
Risk of Cardiovascular Diseases, and
Mortality: A Real-World Study of the Korean
National Health Insurance Service Data.
Nutrients. 2022 Jun 18;14(12):2538. doi:
3390/nu14122538. PMID: 35745268;
PMCID: PMC9230596.
Greenland P, Blaha MJ, Budoff MJ, Erbel
R, Watson KE. Coronary Calcium Score
and Cardiovascular Risk. J Am Coll
Cardiol. 2018 Jul 24;72(4):434-447. doi:
1016/j.jacc.2018.05.027. PMID:
; PMCID: PMC6056023.
Kumar, L. and Das, A.L., 2018. Assessment
of serum lipid profile in patients of
coronary artery disease: a case-control
study. International Journal of
Contemporary Medical Research, 5(5),
pp.59-62.
James Beckerman, MD, FACC on August 20,
Vuorio, A., Watts, G.F., Schneider, W.J.,
Tsimikas, S. and Kovanen, P.T., 2020.
Familial hypercholesterolemia and
elevated lipoprotein (a): double heritable
risk and new therapeutic
opportunities. Journal of internal
medicine, 287(1), pp.2-18.
Ahmadi, A., Panahi, Y., Johnston, T.P. and
Sahebkar, A., 2021. Antidiabetic drugs and
oxidized low-density lipoprotein: A review
of anti-atherosclerotic
mechanisms. Pharmacological
Research, 172, p.105819.
Khatana, C., Saini, N.K., Chakrabarti, S.,
Saini, V., Sharma, A., Saini, R.V. and
Saini, A.K., 2020. Mechanistic insights
into the oxidized low-density lipoproteininduced atherosclerosis. Oxidative
medicine and cellular longevity, 2020.
Martinez, E., Martorell, J. and Riambau,
V., 2020. Review of serum biomarkers in
carotid atherosclerosis. Journal of Vascular
Surgery, 71(1), pp.329-341.
Sternberg M, Pasini E, Chen-Scarabelli C,
Corsetti G, Patel H, Linardi D, Onorati
F, Faggian G, Scarabelli T, Saravolatz L.
Elevated Cardiac Troponin in ClinicalScenarios Beyond Obstructive Coronary
Artery Disease. Med Sci Monit. 2019 Sep
;25:7115-7125. doi:
12659/MSM.915830. PMID:
; PMCID: PMC6774266.
Kalampogias A, Siasos G, Oikonomou E,
Tsalamandris S, Mourouzis K, Tsigkou V,
Vavuranakis M, Zografos T, Deftereos S,
Stefanadis C, Tousoulis D. Basic
Mechanisms in Atherosclerosis: The Role
of Calcium. Med Chem. 2016;12(2):103-
doi:
2174/1573406411666150928111446.
PMID: 26411606.
Abbas, M.N. and Magar, H.S., 2018.
Highly sensitive and selective solid-contact
calcium sensor based on Schiff base of
benzil with 3-aminosalycilic acid
covalently attached to polyacrylic acid
amide for health care. Journal of Solid
State Electrochemistry, 22(1), pp.181-192.
Aydin, S. and Aydin, S., 2019. A new
mechanism of the protamine-dependent
hypotension after cardiopulmonary bypass
and the role of calcium. Cellular and
Molecular Biology, 65(6), pp.28-32.
Shreya, D., Zamora, D.I., Patel, G.S.,
Grossmann, I., Rodriguez, K., Soni, M.,
Joshi, P.K., Patel, S.C. and Sange, I.,
Coronary Artery Calcium Score-A
Reliable Indicator of Coronary Artery
Disease?. Cureus, 13(12).
Jialal I, Singh G. Management of diabetic
dyslipidemia: An
update. (https://www.ncbi.nlm.nih.gov/p
mc/articles/PMC6522756/) World J
Diabetes. 2019 May;10(5):280-290.
Accessed 5/25/2022.
Ali Saleh S, kadhim Khadir F, Al- Alwany
A. THE CLINICAL PROFILE AND
CORONARY ARTERY FINDINGS IN
PATIENTS WITH ATRIAL
FIBRILLATION. JFacMedBagdad
[Internet]. 2022 Apr. 24 [cited 2023 Feb.
;64(1):31-6. Available from:
https://iqjmc.uobaghdad.edu.iq/index.php
/19JFacMedBaghdad36/article/view/1896
Ameen Abdulhasan Al Alwany,
Echocardiographic Assessment of the
Aortic Stenosis Valve Area: Parameters
and Outcome. J. Med. Chem. Sci., 2022,
(7) 1281-1288
https://doi.org/10.26655/JMCHEMSCI.2
7.17 URL:
http://www.jmchemsci.com/article_15473
html
Ameen Al-Alwany. (2021). iatrogenic
atrial septal defect post radiofrequency
ablation in patients with left atrial SVT:
Predictors and outcomes. Revista
Latinoamericana de Hipertensión 16 (3),
-191
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