Triglyceride-glucose index: a surrogate marker of homeostasis model assessment of insulin resistance to predict diabetic nephropathy
Keywords:
T2DM, TyG index, HOMA-IR, diabetic nephropathyAbstract
Diabetes mellitus (DM) is like a cluster of metabolic disorders characterized by high blood sugar levels, disruptions in carbohydrate, protein, and fat metabolism, progressive damage, dysfunction, and failure of various critical organs including the kidneys, eyes, nerves, heart, and blood vessels. Diabetes is expected to impact approximately 537 million people worldwide by 2021, with a global incidence of 10.5%. Because type 2 diabetes (T2DM) progresses slowly, patients should be evaluated for diabetic nephropathy (DN) at the time of diagnosis and every year thereafter.
Downloads
References
Adams-Huet B, Zubirán R, Remaley AT, Jialal I. The Triglyceride-Glucose Index is
Superior to Homeostasis Model Assessment of Insulin Resistance in predicting Metabolic
Syndrome in an Adult Population in the United States. Journal of Clinical Lipidology. 2024
Apr 24.
Liu L, Xia R, Song X, Zhang B, He W, Zhou X, Li S, Yuan G. Association between the
triglyceride–glucose index and diabetic nephropathy in patients with type 2 diabetes: A
cross‐sectional study. Journal of diabetes investigation. 2021 Apr;12(4):557-65.
Mazidi M, Kengne AP, Katsiki N, Mikhailidis DP, Banach M. Lipid accumulation product
and triglycerides/glucose index are useful predictors of insulin resistance. Journal of
Diabetes and its Complications. 2018 Mar 1;32(3):266-70.
Li X, Wang J, Niu L, Tan Z, Ma J, He L, Yu P, Liu X, Li J. Prevalence estimates of the
insulin resistance and associated prevalence of heart failure among United Status adults.
BMC Cardiovascular Disorders. 2023 Jun 10;23(1):294.
Yan S, Wang D, Jia Y. Comparison of insulin resistance-associated parameters in US
adults: a cross-sectional study. Hormones. 2023 Jun;22(2):331-41.
Son DH, Lee HS, Lee YJ, Lee JH, Han JH. Comparison of triglyceride-glucose index and
HOMA-IR for predicting prevalence and incidence of metabolic syndrome. Nutrition,
Metabolism and Cardiovascular Diseases. 2022 Mar 1;32(3):596-604.
Er LK, Wu S, Chou HH, Hsu LA, Teng MS, Sun YC, Ko YL. Triglyceride glucose-body
mass index is a simple and clinically useful surrogate marker for insulin resistance in
nondiabetic individuals. Plos one. 2016 Mar 1;11(3):e0149731.
Moon JH, Kim Y, Oh TJ, Moon JH, Kwak SH, Park KS, Jang HC, Choi SH, Cho NH.
Triglyceride-glucose index predicts future atherosclerotic cardiovascular diseases: a 16-
year follow-up in a prospective, community-dwelling cohort study. Endocrinology and
Metabolism. 2023 Aug;38(4):406.
Mazidi M, Kengne AP, Katsiki N, Mikhailidis DP, Banach M. Lipid accumulation product
and triglycerides/glucose index are useful predictors of insulin resistance. Journal of
Diabetes and its Complications. 2018 Mar 1;32(3):266-70.
Weyman-Vela Y, Guerrero-Romero F, Simental-Mendía LE. The triglycerides and glucose
index is more strongly associated with metabolically healthy obesity phenotype than the
lipid and obesity indices. Journal of Endocrinological Investigation. 2023 Sep 28:1-7.
D'Elia L, Masulli M, Barbato A, Rendina D, Iacone R, Russo O, Strazzullo P, Galletti F.
Triglyceride-Glucose Index, HOMA Index and metabolic syndrome in a sample of adult
men. Minerva Medica. 2024 May 9.
Chen W, Ding S, Tu J, Xiao G, Chen K, Zhang Y, Huang R, Liao Y. Association between
the insulin resistance marker TyG index and subsequent adverse long-term cardiovascular
events in young and middle-aged US adults based on obesity status. Lipids in Health and
Disease. 2023 May 18;22(1):65.
Srinivasan S, Singh P, Kulothungan V, Sharma T, Raman R. Relationship between
triglyceride glucose index, retinopathy and nephropathy in Type 2 diabetes. Endocrinol
Diabetes Metab 2020;4:e00151. doi: 10.1002/edm2.151
Khan SH, Sobia F, Niazi NK, Manzoor SM, Fazal N, Ahmad F. Metabolic clustering of
risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin
resistance. Diabetol Metab Syndr 2018;10:74. doi: 10.1186/s13098-018-0376-8
Cochran WG. Sampling Techniques, 3rd ed. New York, USA: John Wiley & Sons, Inc;
National Kidney Foundation (NKF). Albumin-to-Creatinine Ratio (ACR). [Online] 2021
[Cited 2021 July 13]. Available from URL:
https://www.kidney.org/kidneydisease/siemens_hcp_acr
Mao Q, Zhou D, Li Y, Wang Y, Xu SC, Zhao XH. The TriglycerideGlucose Index Predicts
Coronary Artery Disease Severity and Cardiovascular Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndrome. Dis Markers 2019;2019: 6891537. doi:
1155/2019/6891537
Yamagishi S, Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical
basis and potential therapeutic strategy. Curr Pharm Des 2005;11:2279-9. doi: 10.2174/
Dominguez JH, Tang N, Xu W, Evan AP, Siakotos AN, Agarwal R, et al. Studies of renal
injury III: lipid-induced nephropathy in type II diabetes. Kidney Int 2000;57:92-10. doi:
1046/j.1523-1755. 2000.00814.x
Liang S, Cai GY, Chen XM. Clinical and pathological factors associated with progression
of diabetic nephropathy. Nephrology (Carlton) 2017;22(Suppl 4):s14-9. doi:
1111/nep.13182.
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
