Association of Bcl-2 Associated X Protein (Bax) with Immunopathogenesis of Poly Cystic Ovarian Syndrome
Keywords:
PCOS, Bax, Granulsa cells, Apoptosis, InfertilityAbstract
Polycystic ovary syndrome (PCOS) is one of the most common chronic endocrinopathies affecting women in the reproductive age group. Hirsutism, acne, abnormal menstrual regularity, or obesity are common presenting features in the perimenarcheal stage, Granulosa cells play important role in oocyte maturation, fertilization, and subsequent implantation. Bax was the first Bcl-2 homologue gene to be identified acting asan apoptosis executer. Much research revealed a key role of Bax in the syndrome pathogenesis. Decreased levels of Bax, which is a pro-apoptotic protein, might be involved in the pathogenesis of PCOS. The study aimed to evaluate Bax in serum and estimate its correlation with demographic characteristics. 130 women, 66 patients with PCOS, and 64 regarded as control had estimated their serum levels of Bax, the mean levels were 17.27 in patients and 18.64 in control. The Bax showed a positive association with the immunopathogenesis of PCOS.
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