Prostatic Specific Antigen and its Correlation with Prostatic Cancer in a Sample of Iraqi Population

Authors

  • Muataz Mohammed Al-Taee Department of Medical Laboratories Technology, AL-Nisour University College/Iraq Author
  • Ola Kamal Department of Medical Laboratories Technology, AL-Nisour University College/Iraq Author

Keywords:

Prostate specific antigen, Gleason scores, Prostate cancer

Abstract

This study is directed at prostatic specific antigen (PSA) and its correlation with different Iraqi patients both normal and afflicted with prostatic cancer where numerous patients in Baghdad were screened for this tumor marker and their data collected after testing, this study included (51 ) persons diagnosed with prostatic cancer, collected from Baghdad medical city, and (22) patients as control for screening , both in different age groups (50-59,60-69,70- 79,80-89), results and correlations were calculated using IBM SPSS 20, through observing of the data collected and the comparison with normal standard levels, it is evident that an increase in PSA levels is strongly correlated with tumors of the prostate, also a correlation is apparent between the Gleason scores of prostate cancer patients and also their PSA levels. 

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References

Karen Whalen, Richard Finkel, Thomas A.

Panavelil. Lippincott illustrated reviews:

Pharmacology. Sixth edition. 2014; Page 587.

Nicki R. Coiledge Stuart H. Ralston, Brian R.

Walker. Davidson's principles and practice of

medicine. 21st edition. 2010; Page 258.

Republic of Iraq Ministry of Health Iraqi

Cancer Board. Iraqi Cancer Registry. 2011;

Page 13-40.

Anand P, Kurmumakkara AB, Sundaram C,

Harikumar KB, Tharakan ST, Lai OS, Sung

B, Aggarwal BB. Cancer is a preventable

disease that requires major lifestyle changes.

Pharm Res. 2008; 25:2097-2116.

Bailar JC, Gornik HL. Cancer undefeated. N

Engl J Med. 1997;336:1569-1574

Lew E. and Garfinkel L.A. Mortality at ages

and older 755. 2007; 22:97-101.

T.H. van der Kwast, T. Wiegel, F. Zattoni. in

the cancer prevention study (CPSI). Cancer.

;40-210.

Heidenreich A., Bolla M., Joniau S., Mason

M.D., Matveev V., Mottet N., and Schmid HP. Guidelines on Prostate Cancer. European

Association of Urology. 2010;240-253.

Peyromaure M, Valeri A, Rebillard X,

Beuzeboc P, Richaud P, Soulie M, and

Salomon L . Characteristics of prostate cancer

in men less than 50-year-old. Prog. Urol.

;19,803-809.

Hsing A W, and Chokkalingam AP. Prostate

cancer epidemiology. Frontiers in Bioscience.

;l 1,1388-1413.

NaijisHadiAl-Saadi, AzizH. Jasim. Detectionof

New Marker in Prostate Cancer Patients with

Advanced Bone Metastasis. International

Journal of Cell Science and Biotechnology.

;2320—7574.

Roehrborn C.G., McConell J.D., Bonilla J.,

Rosenblatt S., Hudson P.B. and Malek G.H.

Serum prostate specific antigen is a strong

predictor of future prostate growth in men

with benign prostatic hyperplasia. PROSCAR

longterm efficacy and safety study. J Urol.

;163,13-20.

Greene K.L., Albertsen P.C. and Babaian R.J.

Prostate specific antigen best practice statement.

Update J Urol. 2009;182, 2232-2241.

Lovgren J, PiironenT, Overmo C. Production

of recombinant PSA and HK2 and analysis of

their immunologic cross¬

reactivity. BiochemBiophys Res

Commun.l995;213(3):888-95.

Hara M, Inorre T, Fukuyama T. Some

physicochemical characteristics of gammaseminoprotein, an antigenic component specific

for human seminal plasma. Jpn J Legal Med.

;25:322-324.

Li TS, Beling CG. Isolation and characterization of two specific antigens of

human seminal plasma. FertilSteril.

;24(2):134-44.

Sensabaugh GF. Isolation and characterization

of a semen-specific protein from human seminal

plasma: a potential new marker for semen

identification. J Forensic Sci. 1978; 23(l):106-

Graves HC, Sensabaugh GF, Blake ET.

Postcoital detection of a male-specific semen

protein. Application to the investigation of

rape. N Engl J Med. 1985;312(6):338-43.

Wang MC, Valenzuela LA, Murphy GP.

Purification of a human prostate specific

antigen. Invest Urol. 1979;17(2):159-63.

Papsidero LD, Wang MC, Valenzuela LA,

Murphy GP, Chu TM. A prostate antigen in

sera of prostatic cancer patients. Cancer Res.

;40(7):2428-32.

Stamey TA, Yang N, Hay AR. Prostate¬

specific antigen as a serum marker for

adenocarcinoma of the prostate. N Engl J

Med. 1987;317(15):909-16.

Chou R, Dana T, Bougatsos C, Fu R, Blazina I,

Gleitsmann K. Treatments for Localized Prostate

Cancer: Systematic Review to Update the 2002

U.S. Preventive Services Task Force

Recommendation. Rockville, MD: Agency for

Healthcare Research and Quality (US). 2011;12-

-EF-l.

Allan GM, Chetner MP, Donnelly BJ, Hagen

NA, Ross D, Ruether JD. Furthering the

prostate cancer screening debate (prostate

cancer specific mortality and associated risks).

Can Urol. Assoc. J. 2011;5(6):416-21.

Haythorn MR, Ablin RJ. Prostate-specific

antigen testing across the spectrum of

prostate cancer. Biomark Med.

;5(4):515-26.

Wolf AM, Wender RC, Etzioni RB,

Thompson IM, DAmico AV, Volk RJ.

American Cancer Society guideline for the

early detection of prostate cancer: update

CA Cancer J Clin. 2010;60(2):70-98.

Laux DL, Custis SE. Forensic Detection of

Semen III. Detection of PSA Using

Membrane Based Tests. Sensitivity Issues with

Regards to the Presence of PSAin Other Body

Fluids. Midwestern Association of Forensic

Scientists. 2008;05-ll.

Wimpissinger F, Stiffer K, Grin W, Stackl W.

The female prostate revisited: perineal

ultrasound and biochemical studies of female

ejaculate. The Journal of Sexual Medicine.

;4 (5): 1388-93.

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Published

2023-02-28

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How to Cite

Mohammed Al-Taee, M., & Kamal, O. (2023). Prostatic Specific Antigen and its Correlation with Prostatic Cancer in a Sample of Iraqi Population. History of Medicine, 9(1). http://13.200.237.241/HOM/index.php/medicine/article/view/856