Early detection of Non-alcoholic Liver Disease in type 2 Diabetes mellituslraqi patients by assessment of Transthyretin, clusterin, and retinol binding protein4 with liver of enzymes by Ultrasound imaging
Keywords:
Retinol, Clusterin, and Transthyretin (TTR), Nonalcoholic Fatty Liver Disease (NAFLD); Type 2 Diabetes Mellitus (T2DM); Metaboliciated Fatty Liver Disease (MAFLD) treatment Diabetes mellitus;sonographerfeatures Anthropometric characteristicsAbstract
Background Study role Retinol, Clusterin, and TTR important in understand and treat the pathology of obesity and NAFLD to prevent metabolic syndrome. Treatments for obesity and NAFLD commonly include lifestyle management through weight loss, dietary restriction, exercise, etc. Objective This study was aim to investigate the role of Retinol, Clusterin, and TTR,in the non-alcoholic fatty liver disease and nonalcoholic fatty liver disease NAFLD among the patients with type 2 diabetes mellitus (T2DM). The study will be, done at the National Diabetes Center of Mustansiriyah University. One hundred thirty five subjects with age ranged from (35-65) years were in the serum Retinol, Clusterin, and TTR; concentrations were measured by radioimmunoassay in 150 patients. Diabetic patients were chosen from almost diagnosed patients on follow up visits to the center. The NAFLD diabetic patients were chosen according to clinical features of liver diseases had liver ultrasonic appearance and abnormal liver function tests with Anthropometric characteristics, BMI, HC, and WC, Patients were distributed; three study groups as following: Group one: 50 patients, T2DM with NAFLD Group two: 50 patients, T2DM without NAFLD;Group three 50 healthy controls. Results Retinol, Clusterin, and TTR there was a significant increase it was discovered that there is apositive relationship between transthyretin and that this relationship is statistically significant Conclusions:This study found that transthyretin levels were negatively correlated with the severity of NAFLD in patients with type 2 diabetes. Retinol and Clusterin had a highly significant positive correlation, with Retinol and BMI having a correlation of indicating a substantial effect size. Clusterin had a moderately positive correlation with the protein Clustrin.
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