A study of vitamin D concentration and some physiological variables among patients with beta thalassemia in Kirkuk city
Keywords:
Thalassemia, liver enzymes, ferritin, D dimer, oxidative stressAbstract
The current study aimed to estimate vitamin D concentration and some physiological variables in patients with beta thalassemia. 150 subjects with thalassemia were taken from both Azadi Teaching Hospital and Al Jumhuri Hospital from November 2021 to April 2022. The experimental work was carried out in private laboratories in Kirkuk, Iraq. The volunteers in the current study were divided as follows: 50 healthy volunteers as a control group. 150 thalassemia patients as a second group. The results showed that the activity of liver enzymes showed a significant increase (P < 0.05) in thalassemia patients with beta thalassemia compared to the control group. the ferritin and D dimer concentrations showed a significant increase (P < 0.05) in patients compared to the control group. For oxidative stress, malondialdehyde (MDA) level showed a significant increase (P < 0.05) in patients compared to the control group. The glutathione (GSH), catalase and superoxide dismutase (SOD) concentration showed a significant decrease (P < 0.05) in the patients (0.284 ± 0.025) compared to the control group. the concentration of vitamin D showed a significant decrease (P < 0.05) in patients compared to the control group. It is concluded from the current study that there is a link between thalassemia and liver enzymes, and this indicates the direct effect of beta-thalassemia on the liver. On the other hand, it was found that both ferritin and D dimer can be considered as indicators for the detection of thalassemia. The results of the current study also showed that there is an association between vitamin D deficiency and beta thalassemia.
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ossio MLT, Giesen LF. Araya G. (2016) Hoffbrands Essential
Haematologica 7th Hoffbrand AV Moss PAH editor. Vol. xxxlll.
Wiley Blackwell John Wiely and sons LTD. 73-85 p.
Makroo RN. Bhatia A (2014) provision of ideal transfusions support The
essences of thalassemia care Apollo medicine 11(3):184- 90.
Maria DomenicaCappellini. Alan Cohen, John Porter Ali Taher
VV(2014) guidelines for the management of transfusions dependent
thalassemia 3th. Edit.thalassemia international federations pl-16.
Skirton H, O’Connor A, Humphreys A. Nurses’ competence in genetics:
a mixed method systematic review. J AdvNurs. 2012 Nov; 68(11):
-98.
Aimiuwu E, Thomas A, Roheemun N, Khairallah T, Nacouzi NA,
Georgiou A et al. A Guide for the haemoglobinopathy nurse.
Thalassaemia International Federation. Teamup Creations Ltd. 2012
Awjagh, I. S. A. (2018). Study of zinc and copper in patients with Beta
Thalassemia major and splenctomized in Kirkuk city. Kirkuk
University J. Sci. Stu. 13(1): 239-248.
AHMED, N. H.; AZAD H. F.; NASIR A. and SANA D. J. (2009).
PREVALENCE OF HAEMOGLOBINOPATHIES IN SULAIMANI
- IRAQ. DuhokMedical J. 2(1):71-79
Bashir N, Barkawi M, Sharif L, Momani A, Gharaibeh N. Prevalence of
hemoglobinopathies in North Jordan.Trop GeogrMed 1992; 44(1- 2):122-5.
Yildiz S, Atalay A, Baci H, Atalay EO. Beta -thalassaemiamuations in
Denizili Province of Turkey. Turk J Haematol 2005;22(l):181-5.
El- Hazami MA, Warsy AS. Appraisal of sickle cell and thalassaemia
genes in Saudi Arabia. East Mediterr Health J 1999;5(6):1147-53.
Hassan MK, Taha JY Al-Nama, Widad NM, Jasim SN(2003) frequency
of haemoglobinopthies and glucose 6 phosphate dehydrogenase
deficiency in Basra. East. Med. health J 9:45-54
Al-Nood H(2009)Thalassemia trait in outpatients clinics of Sana city,
Yemen. Hemoglobin 33:242-246. 8. Aydinok (2012)Thalassemia
Hematology 17:28-31.
Khaleel K.J, Hameed AH, Fadhil AM, and Yassin NY.(2009) prevalence
of thalassemia genes in Mousul. Iraqi. J. Of Sci, Supp. 8-10.
Ameli M, Besharati S, Nemati K, Zamani F. Relationship between elevated liver
enzyme with iron overload and viral hepatitis in thalassemia major patients
in Northern Iran.SaudiMed J.2008; 29(11):1611-5.
Ruhl CE, Everhart JE. Relation of elevated serum alanine
aminotransferase activity with iron and antioxidant levels in the
United States. Gastroenterology. 2003; 124: 1821-1829.
Abdalla M, Fawzi M, Salem R, et al. Increased oxidative stress and iron
overload in jordanian pthaassemic children. Hemoglobin.
;35:67- 79.
Company F , Rezaei N , Pourmohmmad B , Gharibi F. Assessment of thyroid
dysfunction in patients with B- thalassemia major (Text in Persian).
Scientific Journal of Kurdistan University of Medical 2008; 13,4(50):37-44.
Wanachiwanawin W, Luengrojanakul P, Sirangkapracha P, Leowattana
W , Fucharoen S. Prevalence and Clinical Significance of Hepatitis C
Virus Infection in Thai Patients with Thalassemia .International
Journal of Hematology 2003;78( 4): 374-378.
Pootrakul, P.; Vongsmasa, V.; La- ongpanich, P. and Wasi, P. Serum
Ferritin Levels in Thalassemias and the Effect of Splenectomy. Acta.
Haematol. 1981; 66(4): 244-50.
Mishra, A. and Tiwari, A. Iron Overload in Beta Thalassemia Major and
Intermedia Patients. Maedica (Buchar). 2013 Sep; 8(4): 328-332.
Easa, Z. Complications of High Serum Ferritin Level after Splenectomy
in p Thalassemic Patients. Kufa Med. Journal. 2009; 12(1): 138-142.
Hallberg L, Bengtsson C, Lapidus L, Lindstedt G, Lundberg PA, Hulten
L. Screening for iron deficiency: an analysis based on bone-marrow
examinations and serum ferritin determinations in a population
sample of women. Br J Haematol 1993;85:787-98.
Zanella, A.; Gridelli, L.; Berzuini, A.; Colotti, MT.; Mozzi, F. and Milani,
S. Sensitivity and Predictive Value of Serum Ferritin and Free
Erythrocyte Protoporphyrin for Iron Deficiency. J Lab Clin Med.
Jan; 113(1): 73-8Hassan MK, Taha JY Al-Nama, Widad NM, Jasim SN(2003) frequency
of haemoglobinopthies and glucose 6 phosphate dehydrogenase
deficiency in Basra. East. Med. health J 9:45-54
Hadi TK, Mohammad NS, Nooruldin SA (2020). Protein C and protein
S levels in patients with major p-thalassemia in Erbil, Kurdistan
Region. Cell MolBiol (Noisy le Grand); 66 (5):25-28.
Travazzi, D., Duca, L., Graziadei, G., Comino, A., Fiorelli, G., and
Cappellini, M.D; Br. J. Haematol. , 112: 48 ; 2001.
Cighetti, G., Duca, L., Bortone, L., Sala, S., Nava, I., Fiorelli, G., and
Cappellini, M.D. ; Eur. J.Clin. Invest., 32: 55 ; 2002.
Chan, A.C. , Chow, C.K. , and Chiu, D.; Proc-Soc. Exp. Biol. Med., 222:
; 1999.
Hershko, C., Link, G., and Cabantchik, I.; Ann. N.Y. Acad. Sci., 850: 191
; 1998.
Abdulkhader, A.A., B.A. Majeed and A.N (2010). Mahmood The Effects
of Chelating Therapy on the Levels of Serum Ferritin, Zinc, Copper
& its relation with Malondialdehyde in Patients with BThalassemia
Major. Iraqi J. Comm. Med.,. (3):147- 152.
Chatterton B.E., Thomas C.M. and Schultz C.G."Liver Density Measured
by DEXA Correlates with Serum Ferritin in Patients with Beta¬
Thalassemia Major" Journal of Clinical Densitometry, 2003; 6(3)
-288.
Dresner P.R., Rachmilewitz E., Blumenfeld A., Idelson M. and Goldfarb
A.W. "Bone Mineral Metabolism in Adults with Beta-Thalassaemia
Major and Intermedia" British Journal of Haematology, Vol. Ill, No.
, Pp. 902- 907, 2000.
EzzatHatoon M., John W.u., Heather M., Leitch Heather A."Vitamin D
Insufficiency and Liver Iron Concentration in Transfusion
Dependent Hemoglobinop
athies in British Columbia" Open Journal of Hematology, 2015; 6-6
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