Effect of Thymus Vulgaris Essential Oil in Experimentally Induced Hyperlipidemic Mice
Keywords:
Anti-hyperlipidemic, High-fat diet, thymus vulgaris, essential oil, antioxidant effects, statin,Abstract
Aim of study is to investigate the possible effect of thymus vulgaris essential oil as anti-hyperlipidemic agent in mice. The. Thirty-two male albino mice were fed a high cholesterol diet for 28 days to construct hyperlipidemic models. The anti-hyperlipidemic activity thymus vulgaris essential oil against hyperlipidemia induced was evaluated in mice. Atorvastatin was used as a standard. Total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured. Compared with normal mice, hyperlipidemic mice possessed significantly higher lipid and liver enzymes profile outcomes. After treatment thymus vulgaris essential oil, lipid levels and liver enzymatic activities in hyperlipidemic mice significantly decreased. Besides that, thymus vulgaris essential oil treated group showed significant improvement in levels of tissue MDA and GPx in hyperlipidemic mice.
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bu-Raghif AR, Sahib HB, Abbas SNJIJPSRR. Anti-hyperlipidemic
effect of Vitex agnus castus Extracts in Mice. 2015;35:120-5.
Trevor AJ, Katzung BG, Masters SB, Kruidering-Hall M. Pharmacology
examination & board review: McGraw-Hill Medical New York; 2010.
Boukhatem MN, Darwish NH, Sudha T, Bahlouli S, Kellou D,
Benelmouffok AB, et al. In vitro antifungal and topical anti¬
inflammatory properties of essential oil from wild-growing Thymus
vulgaris (Lamiaceae) used for medicinal purposes in Algeria: a new
source of carvacrol. 2020;88(3):33.
Fachini-Queiroz FC, Kummer R, Estevao-Silva CF, Carvalho MDdB,
Cunha JM, Grespan R, et al. Effects of thymol and carvacrol,
constituents of Thymus vulgaris L. essential oil, on the
inflammatory response. 2012;2012.
Giordani R, Regli P, Kaloustian J, Mikail C, Abou L, Portugal HJPR.
Antifungal effect of various essential oils against Candidaalbicans.
Potentiation of antifungal action of amphotericin B by essential oil
from Thymus vulgaris. 2004;18(12):990-5.
Thompson JD, Chaichat J-C, Michet A, Linhart YB, Ehlers BJJoce.
Qualitative and quantitative variation in monoterpene co¬
occurrence and composition in the essential oil of Thymus vulgaris
chemotypes. 2003;29(4):859-80.
Mandal S, DebMandal M. Thyme (Thymus vulgaris L.) oils. Essential
oils in food preservation, flavor and safety: Elsevier; 2016. p. 825-34.
Absalan G, Barzegar S. Development and Validation of a Gas
Chromatographic Method for Identification and Quantification of
Thymol and Carvacrol in Pharmaceutical Samples. 2016.
Hoferl M, Buchbauer G, Jirovetz L, Schmidt E, Stoyanova A, Denkova
Z, et al. Correlation of antimicrobial activities of various essential
oils and their main aromatic volatile constituents. 2009;21(5):459-
Youdim KA, Damien Dorman H, Deans SGJJoEOR. The antioxidant
effectiveness of thyme oil, a-tocopherol and ascorbyl palmitate on
evening primrose oil oxidation. 1999;ll(5):643-8.
Dorman HD, Deans SGJJoam. Antimicrobial agents from plants:
antibacterial activity of plant volatile oils. 2000;88(2):308-16.
Vila R. Flavonoids and further polyphenols in the genus Thymus.
Thyme: CRC Press; 2002. p. 158-90.
Jannati N, Gharachorloo M, Honarvar MJJoMp, By-product. Extraction
of thymol compound from Thymus vulgaris L. oil. 2021;10(1):81-4.
Borgarello AV, Mezza GN, Pramparo MC, Gayol MFJS, Technology P.
Thymol enrichment from oregano essential oil by molecular
distillation. 2015;153:60-6.
Salehi B, Mishra AP, Shukla I, Sharifi Rad M, Contreras MdM, Segura
Carretero A, et al. Thymol, thyme, and other plant sources: Health
and potential uses. 2018;32(9):1688-706.
Wang L-X, Liu K, Gao D-W, Hao J-KJWJoGW. Protective effects of two
Lactobacillus plantarum strains in hyperlipidemic mice.
;19(20):3150.
Bancroft J, Stevens AJE, London Melbourne New York. Theory and
practice of histological technique 3rd ED Churchill Livingston.
Ghuffar A, Ahmad T, Mushtaq MNJ, Pharmacology BJo.
Antihyperlipidemic effect of Berberis orthobotrys in hyperlipidemic
animal models. 2014;9(3):377-82.
Aladaileh SH, Saghir SA, Murugesu K, Sadikun A, Ahmad A, Kaur G, et
al. Antihyperlipidemic and antioxidant effects of Averrhoa
carambola extract in high-fat diet-fed rats. 2019;7(3):72.
Kameshwaran S, Jothimanivannan C, Senthilkumar R, Kothai AJP. Anti¬
obesity and hypolipidemic activity of methanol extract of tecoma stans
flowers on atherogenic diet induced obesity in rats. 2013;4(2):77-81.
Firdous SM, Hazra S, Gopinath SC, El-Desouky GE, Aboul-Soud
MAJSjobs. Antihyperlipidemic potential of diosmin in Swiss Albino
mice with high-fat diet induced hyperlipidemia. 2021;28(1):109-15.
Dauqan EM, Abdullah AJJoab, biotechnology. Medicinal and functional
values of thyme (Thymus vulgaris L.) herb. 2017;5(2):017-22.
Yang R-l, Li W, Shi Y-H, Le G-WJN. Lipoic acid prevents high-fat dietinduced dyslipidemia and oxidative stress: A microarray analysis.
;24(6):582-8.
Mahmoud AM, Hernandez Bautista RJ, Sandhu MA, Hussein OEJOm,
longevity c. Beneficial effects of citrus flavonoids on cardiovascular
and metabolic health. 2019;2019.
Yin Y, Yu Z, Xia M, Luo X, Lu X, Ling WJEjoci. Vitamin D attenuates
high fat diet-induced hepatic steatosis in rats by modulating lipid
metabolism. 2012;42(ll):1189-96.
Preiss D, Sattar NJCs. Non-alcoholic fatty liver disease: an overview of
prevalence, diagnosis, pathogenesis and treatment considerations.
;115(5):141-50.
Pessayre D, Mansouri A, Fromenty BJAJoP-G, Physiology L. V.
Mitochondrial dysfunction in steatohepatitis. 2002;282(2):G193-G9.
Ayala A, Munoz MF, Arguelles SJOm, longevity c. Lipid peroxidation:
production, metabolism, and signaling mechanisms of
malondialdehyde and 4-hydroxy-2-nonenal. 2014;2014.
Melov SJTijob, biology c. Animal models of oxidative stress, aging, and
therapeutic antioxidant interventions. 2002;34(11):1395-400.
Gholami Ahangaran M, Ahmadi Dastgerdi A, Azizi S, Basiratpour A,
Zokaei M, Derakhshan MJVM, et al. Thymol and carvacrol
supplementation in poultry health and performance. 2022;8(l):267-88.
Ali-Shtayeh MS, famous RM, Abu-Zaitoun SY, Akkawi RJ, Kalbouneh SR,
Dudai N, et al. Secondary treated effluent irrigation did not impact
chemical composition, and enzyme inhibition activities of essential
oils from Origanum syriacum var. syriacum. 2018;111:775-86.
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