The role of lnterleukin-6 with Heart Failure: A CaseControl study
Keywords:
heart failure, IL-6, EF%, inflammation, interleukinAbstract
Background: Systemic inflammatory response has been documented as a common physiopathologic feature of heart failure (HF). Plentiful studies have shown that patients with HF have increased expression and release of inflammatory cytokines. IL-6 is associated with LVEF in people, independent of probable confounders. The objective of this work was to pinpoint and describe the association between IL-6 and heart failure. Material and methods: The study was a case-control, including 160 participants, comprising 80 patients with HF and a random group of 80 healthy control subjects. A left ventricular ejection fraction of less than 50% was used to identify HF with diminished ejection fraction. All participants were subjected to a hematological assessment of IL-6, and the results were matched with the control group. Results: Significantly higher IL-6 serum levels among the patients compared with the control and also among NYHA classes of HF. A non-significant difference in heart failure patients between the non-anemic and anemic patients regarding IL-6 levels. A highly significant negative correlation between IL-6 and LVEF% among patients with HF was also found. Conclusion: The results of the present study point to a strong relationship between IL-6 and HF and provide preliminary support for further research into any potential therapeutic uses of IL-6 in the prevention of HF. In general pubulation, interleukin-6 may be a promising biomarker for the emergence of HF.
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References
Furman, D., Campisi, Judith, Verdin, Eric, Carrera-Bastos, Pedro,
Targ, Sasha, Franceschi, Claudio, et al., Chronic
inflammation in the etiology of disease across the life span.
Nature Medicine, 2019. 25(12): p.1822-1832.
Ahmed KA et al., Association of Tumor Necrosis Factorand Myeloperoxidase enzyme with Severe Asthma: A
comparative study. Reports of Biochemistry &
Molecular Biology, 2022. 11(2): p. 239-46.
Al-Agam A. et al., The Association of Depressive Symptoms
With Plasma C-Reactive Protein in Patients With Major
Depressive Disorder Under Treatment. Iranian
Rehabilitation Journal, 2021. 19(4): p. 425-432
Abd., H, et al., The Utility of Serum IL-1 and CRP Together with
Fractional Exhaled Nitric Oxide in the Diagnosis of Asthma
in Adults. NeuroQuantology, 2021.19(8): p.119-124.
Amer FA., Inflammatory Associations of Peripheral
Oxytocin, C-Reactive Protein Levels with Depression
Among Adult Age Group with Major Depressive
Disorder. Clinical Schizophrenia & Related Psychoses,
Amjed HA. et al., The Role of Serum IL-1 in Combination
with Fractional Exhaled Nitric Oxide in the Diagnosis of
Adult Bronchial Asthma. NeuroQuantology, 2021. 19(9):
p. 13-19.
Asseel KS. et al., Biochemical Significance of Cystatin-C
and High Sensitive CRP in Patients with Acute Coronary
Syndrome; any Clinical Correlation with Diagnosis and
Ejection Fraction. Sys Rev Pharm, 2020. 11(3): p. 8.
Qayssar JF. et al., Evaluation of Practice of Prescribing and
Monitoring Anticoagulants Among Hospitalized Iraqi
Patients. HIV Nursing, 2022. 22(1): p. 71-76.
Ponikowski, P., et al., 2016 ESC Guidelines for the diagnosis
and treatment of acute and chronic heart failure: The
Task Force for the diagnosis and treatment of acute
and chronic heart failure of the European Society of
Cardiology (ESC). Developed with the special
contribution of the Heart Failure Association (HFA) of
the ESC. Eur J Heart Fail, 2016. 18(8): p. 891-975.
Al Sa'ady AT. et al., Brush Up Your Teeth to Brush Up Your
Heart: A Clinical Review on the Association of Oral
Hygiene with Cardiovascular Diseases. International
Journal of Innovative Science and Research Technology
6(12): p. 7.
Al-Shamma Y. et al., Caries Burden is associated with
serum uric acid and CRP in Patients Treated for Acute
Coronary Syndrome. Journal of Chemical Health Risks,
12(2): p. (Accepted).
Gullestad, L., et al., Inflammatory cytokines in heart failure:
mediators and markers. Cardiology, 2012. 122(1): p. 23-
Nagham Y. et al., The Estimation Levels Of 11-6 And 11-18 As
Inflammatory Biomarkers In Obese And Non Obese
Pateints With Allergic Rhinitis. Plant Archives 2019. 19:
p. 860- 863
Libby, P., Rocha, Viviane Zorzanelli, All roads lead to IL-6: A
central hub of cardiometabolic signaling. International
Journal of Cardiology, 2018. 259: p. 213-215.
Ridker, PM., Rifai, Nader, Stampfer, Meir J, Hennekens,
Charles H. Plasma concentration of interleukin-6 and
the risk of future myocardial infarction among
apparently healthy men. 2000. Circulation. 101(15): p.
-1772.
Chia, YC., et al., Interleukin 6 and Development of Heart
Failure With Preserved Ejection Fraction in the General
Population. 2021. 10(11): p. e018549.
Martin D., New York Heart Association, Nomenclature and
Criteria for Diagnosis of Diseases of the Heart and
Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co,
: p. 253-256.
Schwinger, RH., Pathophysiology of heart failure.
Cardiovasc Diagn Ther, 2021. 11(1): p. 263-276.
Markousis-Mavrogenis, G., et al., The clinical significance of
interleukin-6 in heart failure: results from the BIOSTATCHF study. Eur J Heart Fail, 2019. 21(8): p. 965-973.
Kalogeropoulos, A., et al., Inflammatory markers and
incident heart failure risk in older adults: the Health
ABC (Health, Aging, and Body Composition) study. J
Am Coll Cardiol, 2010. 55(19): p. 2129-37.
Suzuki, H., et al., Time-course of changes in the levels of interleukin
in acutely decompensated heart failure. Int J Cardiol, 2005.
(3):p. 415-20.
Chapman, B.P., et al., Gender, race/ethnicity, personality,
and interleukin-6 in urban primary care patients. Brain
Behav Immun, 2009. 23(5): p. 636-42.
Bahrami, H., et al., Differences in the incidence of
congestive heart failure by ethnicity: the multi-ethnic
study of atherosclerosis. Arch Intern Med, 2008. 168(19):
p. 2138-45.
Wu, CK., et al., Plasma levels of tumor necrosis factorand interleukin-6 are associated with diastolic heart
failure through downregulation of sarcoplasmic
reticulum Ca2+ ATPase. Crit Care Med, 2011. 39(5): p.
-92.
Van Linthout, S. and C. Tschbpe, Inflammation - Cause or
Consequence of Heart Failure or Both? Curr Heart Fail Rep,
14(4): p. 251-265.
Rose-John, S., IL-6 trans-signaling via the soluble IL-6
receptor: importance for the pro-inflammatory
activities of IL-6. Int J Biol Sci, 2012. 8(9): p. 1237-47.
Nemeth, E., et al., Hepcidin, a putative mediator of anemia
of inflammation, is a type II acute-phase protein. Blood,
101(7): p. 2461-3.
Nemeth, E., et al., IL-6 mediates hypoferremia of
inflammation by inducing the synthesis of the iron
regulatory hormone hepcidin. J Clin Invest, 2004. 113(9):
p. 1271-6.
Jankowska, EA., et al., Iron deficiency and heart failure: diagnostic
dilemmas and therapeutic perspectives. Eur Heart J, 2013.
(11): p. 816-29
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