The Relationship between Ejection Fraction and Cardiac Biochemical Parameters in Left Bundle Branch Block Patients
Keywords:
cardiac biochemical markers, LBBB and Ejection fraction.Abstract
Introduction: This study evaluates the correlation between ejection fraction (EF) and many biochemical cardiac markers in patients with left bundle branch block (LBBB). The heart's ability to pump blood can be negatively affected by LBBB, a frequent conduction defect. An essential measure of cardiac function, EF, is the amount of blood pushed out of the left ventricle during each contraction. Aim: This study aims to better understand the relationships between EF and cardiac biochemical markers in individuals with LBBB and the biological implications of these findings. Material and methods: A case-control study was performed with 140 participants (70 LBBB patients and 70 healthy controls). The diagnoses were verified by clinical and laboratory testing, and serum samples were analyzed for cardiac biomarker levels. In addition, participants' ages, sexes, BMIs, employment statuses, and occupations were analyzed in addition to other demographic data. Results: Age, body mass index, employment and occupational status were all shown to be significantly different between LBBB patients and healthy controls. In addition, h-FABP, myoglobin, troponin, NT-proBNP, and CK-MB were considerably greater in LBBB patients than in healthy controls. These biomarkers have the potential to serve as indications of cardiac dysfunction in LBBB patients, as shown by a correlation matrix revealing substantial connections between them. Conclusions: In LBBB patients, these biomarkers may indicate cardiac dysfunction, as shown by these results. This work contributes to risk classification, prognosis evaluation, and therapeutic decision-making in LBBB patients by shedding light on the connection between EF and cardiac biochemical markers. Further investigation needs to be conducted to confirm these results and investigate possible approaches for improved patient care.
Downloads
References
J. W. Hurst, "Left Bundle-branch Block—Pathophysiology,
Prognosis, and Clinical Management," Clin. Cardiol., vol.
, no.10, p. 535, 2007.
R. Rorth et al., "Circulation: Heart Failure Comparison of
BNP and NT-proBNP in Patients With Heart Failure and
Reduced Ejection Fraction," no. February, pp. 1-10, 2020,
doi:10.1161/CIRCHEARTFAILURE.119.006541.
F. S. Apple et al., "Future Biomarkers for Detection of
Ischemia and Risk Stratification in Acute Coronary
Syndrome," vol. 824, pp. 810-824, 2005, doi:
1373/clinchem.2004.046292.
S. Baldasseroni et al., "Left bundle-branch block is
associated with increased 1-year sudden and total
mortality rate in 5517 outpatients with congestive heart
failure: a report from the Italian network on congestive
heart failure," Am. Heart J., vol. 143, no. 3, pp. 398-405,
M. Steenman and G. Lande, "Cardiac aging and heart
disease in humans," Biophys. Rev., vol. 9, no. 2, pp. 131-
, 2017.
K. C. Koskinas and A. Ziakas, "Left bundle branch block in
cardiovascular disease: clinical significance and
remaining controversies," Angiology, vol. 66, no. 9. SAGE
Publications Sage CA: Los Angeles, CA, pp. 797-800,
K. B. Lewandrowski, Cardiac Markers, An Issue of Clinics in
Laboratory Medicine, vol. 34, no. 1. Elsevier Health
Sciences, 2014.
N. Zagidullin et al., "Combining novel biomarkers for risk
stratification of two-year cardiovascular mortality in patients
with ST-elevationmyocardialinfarction,"J. Clin. Med.,vol.9, no.
, p. 550, 2020.
M. I. Ahmad and N. Sharma, "Biomarkers in acute
myocardial infarction," J Clin Exp Cardiol., vol. 3, no. 11, p.
, 2012.
I. Ramasamy, "Biochemical markers in acute coronary
syndrome," Clin. Chim. acta, vol. 412, no. 15-16, pp. 1279-
, 2011.
V. Loria, M. Leo, G. Biasillo, I. Dato, and L. M. Biasucci,
"Biomarkers in acute coronary syndrome," Biomark.
Insights, vol. 3, p. BMI-S588, 2008.
M. M. Yousif, R. M. H. Al-Salih, and A. T. Al-Khafaji, "Study of the
Correlation between Brain natriuretic peptide and Each of
Malondialdehyde, Ceruloplasmin and Transferrin in patients
with Heart failure (HF) in Thi-Qar Governorate," Thi-Qar
Med. J., vol. 8, no.1, 2014.
M. Lichtenauer et al., "A comparative analysis of novel
cardiovascular biomarkers in patients with chronic heart
failure," Eur. J. Intern. Med., vol. 44, pp. 31-38, 2017.
S. Sanders-van Wijk et al., "Circulating biomarkers of
distinct pathophysiological pathways in heart failure
with preserved vs. reduced left ventricular ejection
fraction," Eur. J. Heart Fail., vol.17, no.10, pp.1006-1014,
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.