Green Synthesis of Mn3O4 Nanoparticles using chia seeds extract, characterization, and cytotoxicity on the HL-60 cells
Keywords:
Mn3O4 nanoparticles, HL-60 cells, chia seedsAbstract
In medicine, nanoparticles are successfully replacing anticancer drugs (NPs). In this study, Mn3O4-NPs were made using the green chemistry Chia seed extract method, and they were then characterized using various methods, including FTIR, XRD, EDX, and SEM. HL-60 cells were tested against Mn3O4 nanoparticles at varied concentrations (20, 40, 80, and 160 µg/ml), with an average size of 35.27 nm in the XRD. After 24 hours, the killing rate was 4%, 14%, 24%, and 40% in that sequence. Moreover, the rates were (4%, 26%, 44%, and 40%) in that sequence after 48 hours. Half-maximal inhibitory concentrations (IC50) for Mn3O4 -NPs are 220.5 at 24 hours and 97.83 at 48 hours. Mn3O4 nanoparticles offer potential therapeutic advantages as anticancer drugs. The drug was safe at all concentrations (not harmful).
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