The Role of collagen Supplement to The Improvement of Insulin Resistance
S. aureus, 16srRNA gene, agr system, antibiotic resistance
Keywords:
insulin resistance, Type 2 diabetes, TyG index, glycine, collagen, insulin secretion, HOMA-1.Abstract
Background Insulin resistance is a problem that many of us suffer from. It has been studied from several aspects, including changing the lifestyle through exercise, limiting the high-carbohydrate diet, and through proven facts about glycine through its role as a precursor for several crucial metabolites, including creatine, haem, porphyrins, and glutathione. Glycine functions as a neurotransmitter in the central nervous system and has a variety of functions in peripheral and nervous tissue, including immunomodulatory, cryoprotective, antioxidant, and anti-inflammatory effects. These facts have sparked research into the role of glycine in lowering insulin resistance. Objective: Studying the level of glycine as a major amino acid in the formation of collagen in the case of insulin resistance and, simultaneously, studying the possibility of using it as a treatment for the condition. Subjects, Material, and Method: Analytical cross-sectional and cohort designs are the two types of statistical designs. The study was conducted on 160 volunteers, recruited at the beginning of the study and chosen from an age group based on the study data and the preliminary analysis, with ages ranging from (40-70 years). They were separated into two groups: the first group includes 80 individuals, after adopting an average body mass index of more than 25, who suffer from insulin resistance, and the second group includes 80 healthy individuals who do not suffer from insulin resistance and whose body mass index is less than 25. It was determined Blood glucose, lipid profile, and HBA1C using Cobas c111 on serum samples from both groups. Fasting insulin was determined using Cobas E411 and serum glycine using ELISA kits. Results: Individuals with insulin resistance have significantly lower serum glycine levels (p≤ and diabetes finding of studied (0.05) in comparison with healthy individuals without insulin resistance, and after collagen (1tab/day) at fasting state supplement show a significant decrease in the level of serum fasting glucose, triglyceride, fasting insulin, homeostatic model of assessment insulin resistance (HOMA-IR) and triglyceride-Glucose index (TyG). Conclusion: The level of glycine is low in people who have insulin resistance, and at most, according to the results, its decrease is one of the causes of insulin resistance. At the same time, collagen pills can be adopted as a preventative treatment for insulin resistance.
Downloads
References
Alves, A., Bassot, A., Bulteau, A.L, Pirola, L and Morio, B.,
Glycine metabolism and its alterationsin obesity
and metabolic diseases. Nutrients,11(6), p.1356
Mahmoud, H.G., Circulating resistin concentrations,
inflammatory biomarkers and insulin resistance in
Iraqi patients with chronic kidney failure.
Saleh, B.O., Majeed, M.J. and Oreaby, G.M., 2014. Irisin
impact as a medication that ameliorate and
hinder the development of insulin resistance
associated disorders without regular exercise
(experimental study). IOSR Journal of Dental and
Medical Sciences, 13(9), pp.28-35.
Al-Khafajy, D.A., Majeed, M.J., Al-Azzawi, O.F. and
Khaleel, A.L, 2021. Role of CoQ1O and IGFBP-1 in
Obese Male Patients with Diabetic Mellitus Type
II. Indian Journal of Forensic Medicine &
Toxicology,15(1), pp.22O4-22O9.
ABED, E., Dr Manal K Rasheed and Dr Khalaf G.Hussein
(2022) "Assessment of Total Procollagen Type 1 IntSact
N-terminal Propeptide, C-telopeptide of type1collagen,
Bone Mineral Density and its Relationship to Body Mass
Index in Men with Type 2 Diabetes", Journal of the
Faculty of Medicine Baghdad, 64(2), pp. 81-85. doi:
32007/jfacmedbagdad.6421942
Yan-Do, R. and MacDonald, P.E., 2017. Impaired
"glycine"-mia in type 2 diabetes and potential
mechanisms contributing to glucose homeostasis.
Endocrinology, 158(5), pp.1064-1073.
Scirica, B.M., 2017. Use of biomarkers in predicting the
onset, monitoring the progression, and risk
stratification for patients with type 2 diabetes
mellitus. Clinical chemistry, 63(1), pp.186-195.
Hernandez-Baixauli, J., Puigbo, P., Torrell, H.,
Palacios-Jordan, H., Ripoll, V.J.R., Caimari, A., Del
Bas, J.M., Baselga-Escudero, L and Mulero, M.,
A Pilot Study for Metabolic Profiling of
Obesity-Associated Microbial Gut Dysbiosis in
Male Wistar Rats. Biomolecules, 11(2), p.3O3.White, P.J., McGarrah, R.W., Herman, M.A., Bain, J.R.,
Shah, S.H. and Newgard, C.B., 2021. Insulin action,
type 2 diabetes, and branched-chain amino acids:
a two-way street. Molecular metabolism, 52,
p.101261.
Imenshahidi, M. and Hossenzadeh, H., 2022. Effects of
glycine on metabolic syndrome components: a review.
Journal of Endocrinological Investigation, pp.1-13.3.
Barik, S., 2021. An analytical review of the structural
features of pentatricopeptide repeats: Strategic
amino acids, repeat arrangements, and
superhelical architecture. International Journal of
Molecular Sciences, 22(10), p.5407.
Ryan, P.J., Riechman, S.E., Fluckey, J.D. and Wu, G.,
Interorgan metabolism of amino acids in
human health and disease. In Amino Acids in
Nutrition and Health (pp.129-149). Springer, Cham
Abdulrahman, Z., Alatrakji, M. G., Al-Maliky, A. A.,
Hussein, K. I. and Hussain, S. A. (2023) "Influence
of Metformin Dose and Treatment Adherence on
Glycemic Control, Adiposity, and Cardiovascular
Risk Markers in Iraqi Patients with T2DM", Journal
of the Faculty of Medicine Baghdad, 64(4), pp.
-226. doi: 10.32007/jfacmedbagdad.6441939.
Chopra, A.K., 2020. Metabolic syndrome or insulin
resistance: evolution, controversies and
association with cardiovascular disease risk.
Indian Journal of Clinical Cardiology,1(2), pp.77-85
Chao, Y.P., Kao, T.W., Chang, Y.W., Peng, T.C., Chen, W.L
and Wu, L.W., 2020. Utilization of anthropometric
parameters as a novel tool for detection of insulin
resistance. Clinical Nutrition, 39(8), pp.2571-2579
Wondmkun, Y.T., 2020. Obesity, insulin resistance,
and type 2 diabetes: associations and therapeutic
implications. Diabetes, metabolic syndrome and
obesity: targets and therapy, 13, p.3611.
Adhav, N.R. and Deore, B.V., 2022. ROLE OF
NUTRACEUTICALS IN METABOLIC SYNDROME,
pp.11(12), 782-809.
Guevara-Cruz, M., Vargas-Morales, J.M., MendezGarcia, A.L., Lopez-Barradas, A.M., GranadosPortillo, O., Ordaz-Nava, G., Rocha-Viggiano, A.K.,
Gutierrez-Leyte, C.A., Medina-Cerda, E., Rosado,
J.L. and Morales, J.C., 2018. Amino acid profiles of
young adults differ by sex, body mass index, and
insulin resistance. Nutrition, Metabolism and
Cardiovascular Diseases, 28(4), pp.393-401.
Zhang, J., Ni, Y., Qian, L., Fang, Q., Zheng, T., Zhang,
M., Gao, Q., Zhang, Y., Ni, J., Hou, X. and Bao, Y.,
Decreased abundance of Akkermansia
muciniphila leads to impaired insulin secretion and
glucose homeostasis in lean type 2 diabetes.
Advanced Science, 8(16), p.2100536
Devasia, S., Kumar, S., Stephena, P.S., Inoue, N.,
Sugihara, F. and Suzuki, K., 2018. Double blind,
randomized clinical study to evaluate efficacy of
collagen peptide as add on nutritional supplement
in Type 2 diabetes. J. Clin. Nutr. Food Sci, 1, pp.6-
Janssen, J.A., 2021. Hyperinsulinemia and its pivotal
role in aging, obesity, type 2 diabetes,
cardiovascular disease and cancer. International
Journal of Molecular Sciences, 22(15), p.7797.
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.