Spectrophotometric assessment of Amino drugs employing flow injection analysis and cloud point extraction techniques
Keywords:
Cefotaxime, Batch method, Cloud point extraction, Flow injection analysis.Abstract
The first method on the oxidative coupling Cefotaxime reaction with 2,4- dinitrophenyl hydrazine and Sodium hydroxide to produce a soluble Reddish- Orange dye product was devised to estimate the Cefotaxime in bulk and pharmaceutical preparation. The concentration range is between 1 and 50 g/mL. Beer's law is met by the product in terms. With a molar absorptivity of 6.6×104L.mol-1.cm-1 and a correlation coefficient of 0.9995, Sandell's sensitivity is 6.85×10¯³ g.cm-2 at wave length 615 nm. A second technique for determining a trace amount in an aqueous solution product is called cloud point extraction (CPE), and it is based on measurements made with a UV-visible spectrophotometer at a wavelength of 610 nm. The correlation coefficient was 0.9995 and the Beer's law concentration range was 0.25–6 g/mL The molar absorptivity was 1.4×104 L.mol-1.cm-1. Pre-concentration 25, detection of limit 0.021 µg/mL. The distribution coefficient (D) was 298.97, and enrichment factor was 18.59. The last method is flow injection analysis, which is straightforward to estimate. The Beer's law concentration range was 2-150 µg / mL, Sandell's sensitivity is 0.11 µg.cm-2 at 605 nm, with a molar absorptivity of 4×103 L.mol-1.cm-1 and correlation coefficient was 0.9995, it is successfully used for drug estimation. Qualities in a straightforward situation or pharmacological formulations
Downloads
References
Hartman SJF, Brüggemann RJ, Orriëns L et
al. Pharmacokinetics and target attainment
of antibiotics in critically Ill children: A
systematic review of current literature.
Clin Pharmacokinet 2020.
Nanda R, Bhagwat V, Potawale S, et al.
Development and validation of a HPTLC
method for simultaneous densitometric
analysis of cefotaxime sodium and
sulbactam sodium as the bulk drugs and in
the pharmaceutical form. Pharm Res. 3:
-1669; 2010.
Mostafa F. Al-Hakkani; HPLC Analytical
Method Validation for Determination of
Cefotaxime in the Bulk and Finished
Pharmaceutical Dosage Form; Sustaniable
Chemical Engineering; Volume 1 Issue;
Hoang VD, Loan NT, Tho VT, Nguyen HM.
U V spectrophotometric simultaneous
determination of cefoperazone and
sulbactam in pharmaceutical formulations
by derivative, Fourier and wavelet
transforms. Spectrochim Acta A Mol
Biomol Spectrosc. 2014;121(1):704-714.
Sha OU, Liao YN, Zhou YN, Zhang SI,
Weixng MA. Determination of
cefoperazone sodium in pharmaceutical
formulations by Fe3+-Phenanthroline
spectrophotometry. Asian J
Chem.;25(11):5965-5967; 2013.
Lalitha N, Puranik SB, Pai PNS, A stability
indicating HPLC method for
cefoperazone. Eurasian J Anal Chem.;4
(1):110- 118; 2009.
Sumayha Mohammed Abbas;
Spectrophotometric Determination of
Cefotaxime via Diazotization Reaction in
Pure and Pharmaceutical Samples; Ibn AlHaitham Jour. for Pure & Appl. Sci.; Vol.
(2) 2017.
Mouyed Q. Al-Abachi, Hind S. Al-Ward,
Yassmin H. Mohammad; BATCH AND
FLOW-INJECTION
SPECTROPHOTOMETRIC
DETERMINATION OF SODIUM
CEFOTAXIME IN
PHARMACEUTICAL
PREPARATIONS; Iraqi Journal of
Science, vol.53, No.2, pp 241-249; 2012.
Mengmeng Dou, JinWang, BoruGao, CeXu,
FanYang; Mesoporous g-C3N4
photocatalyzes the degradation of
amoxicillin and cefotaxime under visible
light: Mechanism, degradation pathway,
and DFT calculation; Chemical
Engineering Journal; Volume 383; 123134;
March 2020.
LAMYA A. SARSAM1, SALIM A.
MOHAMMED2 and SAHAR A. FATHE;
Spectrophotometric and RP-HPLC
Methods for Determining Cefotaxime
Sodium in Pharmaceutical Preparations;
AJ C SIAN OURNAL OF HEMISTRY
https://doi.org/10.14233/ajchem. 22524;
N. K. Abood, M. J. M. Hassan, and M. A.
Al-Da’amy, “Spectrophotometric
determination methyldopa and salbutamol
by oxidative coupling, cloud point and
flow injection in pharmaceutical
formulations,” International Journal of
Drug Delivery Technology, vol. 9, no. 2,
pp. 182–192, Apr. 2019.
P. Guo, X. Li, J. Wang and A. You, J. Pharm.
Biomed. Anal., 43, 1849 (2007);
https://doi.org/10.1016/j.jpba.2006.12.009
C.H.L. Saranya, J.C. Thejaswini, B.M.
Gurupadayya and B.Y.K. Sruthi, IOSR J.
Pharm., 4, 12 (2014).
P.S. Jain, M.K. Patel, A.J. Chaudhari and S.J.
Surana, Indian J. Pharm. Educ. Res., 46,
(2012)
N. K. Abood and M. J. M. Hassana,
“Spectrophotometric Determination of
Sulfadoxine Drug use Cloud point and
Flow injection Methods in Pharmaceutical
Formulations,” Egypt J Chem, vol. 64, no.
, pp. 2913–2924, Jun. 2021, doi:
21608/EJCHEM.2021.55297.3164.
J. Du and H. Li, Appl. Spectrosc., 64, 1154
(2010);
https://doi.org/10.1366/000370210792973613
K. Nikolic, M. Aleksic, V. Kapetanovic and D.
Agbaba, J. Serb. Chem. Soc., 80, 1035 (2015);
https://doi.org/10.2298/JSC150129019N
M.Q. Al-Abachi, H.S. Al-Ward and Y.H.
Mohammad, Iraqi J. Sci., 53, 241 (2012).
L.P. Consortti and H.R.N. Salgado, J. Pharm.
Sci. Emerg. Drugs, 5, 1 (2017);
1000118R. Wang, Z.P. Jia, J.J. Fan, J. Ma, X. Hua,
Q. Zhang and J. Wang, Pharmazie, 64,
(2009).
M.A. Omar, O.H. Abdelmageed and T.Z.
Attia, Int. J. Anal. Chem., 5, 12 (2009).
N.S.T. Al-Awadie and M.H. Ibraheem, Int. J.
Res. Pharm. Chem., 6, 891 (2016).
L.-L. Wu, Y. Zhang, W. Zhao and Q.-M. Li,
J. Chin. Chem. Soc., 55, 550 (2008).
Hesham Salem, Ebtihal Samir; Determination
of cefotaxime, cefoperazone, ceftazidime
and cefadroxil using surface plasmon
resonance band of silver nanoparticles;
Brazilian Journal of Pharmaceutical
Sciences http://dx.doi.org/;54(3):e17565;
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.