Estimation of Interleukin 17A Gene Polymorphism in Patients with Polycystic Ovary Syndrome
Keywords:
Polycystic ovary syndrome, Interleukin17A gene (rs2275913) polymorphismAbstract
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with a vital genetic component and is characterized by polycystic ovaries, hyperandrogenemia, and menstrual irregularity. Methods: A case-control study includes 50 PCOS-affected women and 50 healthy women as a control group. Whole blood was used for DNA extraction. DNA extraction was used to detect Interleukin-17A gene polymorphism (rs2275913) usingReal-Time Polymerase Chain Reaction (RT-PCR). Results: Regarding the genotypes of IL-17A gene (rs2275913) polymorphism, there were no significant differences between the studied group (P=0.421).The AG genotype was at a higher frequency in patients compared with control (50% vs. 42%, respectively); also, the AA genotype was elevated in patients compared with control (16% vs. 12%, respectively).In the alleles frequency, there were no significant differences between the studied group (P=0.307). Conclusion:The result of this study has shown that the IL-17A gene (rs2275913) polymorphism maybe have a protective role in PCOS.Further studies are requiredto demonstrate the role of this polymorphism in PCOS disease.
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