Evaluation the Role of Amylin Hormone and some Biochemical Parameters in Type 2 Diabetic Patients with Cardiovascular disease
Keywords:
Myocardial infraction, Type 2 diabetes, Amylin, Creatin phospho kinase, Lipid profile.Abstract
Background: Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. The study aimed to observe levels the Amylin, Creatine phospho kinase (CPK), Total cholesterol (TC), Triglycerides (TG), High density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Also to evaluate correlation between (Amylin, CPK, TC, TG, HDL, LDL and VLDL). Methods: Serum Amylin, CPK, TC, TG, HDL, LDL and VLDL levels were determined in 50 patients with acute myocardial infraction, 50 patients with (type 2 diabetes with myocardial infraction) and 50 healthy subjects. Results: The results show a significant increase in the concentration of serum (amylin, CPK, TC, TG, LDL and VLDL) in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p≤0.05). But it was found no significant deference in the concentration of serum amylin between (AMI and controls) groups (p≤0.05). Also it was found no significant deference in the concentration of serum CPK between (T2DM with AMI and AMI) groups (p≤0.05). While it was found a significant decrease in the concentration of serum HDL in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p≤0.05). It was found a positive correlation between serum amylin and ( CPK, TC, TG, LDL and VLDL) and a negative correlation between serum amylin and HDL. Conclusion: We finding a positive correlation between amylin and (CPK, TC, TG, LDL and VLDL). Also we finding negative correlation between amylin and HDL
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References
Ahmad AJ, Khan A, Khan S, Manzoor K.
Causes, complication and management of
diabetes mellitus. Chronicle Journal of
food and Nutrition 2017; 1:1-3.
Al- Abbas. Evaluation the Role of Interleukin-
and Interleukin-10 in Myocardial
Infarction Patients in Al- Najaf City.
University of Thi-Qar Journal Of Science.
; 7(1): 84-88.
Allain Charles C, et al. Rapid single-step
kinetic colorimetric assay for lactate
dehydrogenase in serum. Clinical
Chemistry, 1973; 19.2: 223-227.
Auda A Mohammed, Majid A, Al-Fartosi G
Khalid. Protective role of polyphenolic
compounds extracted from cyperus rotundus
rhizomes and taurine on troponin-I and some
oxidant/antioxidants parameters of female rats
treated with isoproterenol – induced
myocardial infraction. Journal of Thi-Qar
University. 2018; 13. 2: 61-76.
Chang Chih-Chun, et al. Creatine kinase (CK)-
MB-to-Total-CK ratio: a laboratory
indicator for Primary cancer
screening. Asian Pacific Journal of Cancer
Prevention, 2015; 16.15: 6599-6603.
Ejan Aoife M, Dinneen Seán F. What is
diabetes?. Medicine, 2019; 47.1: 1-4.
Fossati Plero, Prencipe Lorenzo. Serum
triglycerides determined colorimetrically
with an enzyme that produces hydrogen
peroxide. Clinical chemistry, 1982; 28.10:
-2080.
Friedwald WT, Levy R I, Fredrickson D S.
Estimation of Concentration of LDL-C in
Plasma without the Use of Preparative
Ultracentrifuge. Clinical Chemistry , 1972;
: 499–502.
Graham I, Atar D, Borch-Johnsen K, Boysen
G, Burell G, Cifkova R, Dallongeville J, De
Backer G, Ebrahim S, Gjelsvik B. European
Guidelines on Cardiovascular Disease
Prevention in Clinical Practice, Heart J ,
; 28: 2375–414.
Harreiter Jürgen et al. IADPSG and WHO
gestational diabetes mellitus criteria
identify obese women with marked insulin
resistance in early pregnancy. Diabetes
care, 2016; 39.7: e90-e92.
Hay Debbie L, et al. Amylin: pharmacology,
physiology, and clinical potential,
Pharmacological reviews, 2015; 67, 3: 564-
Hess Joseph W, Mtjrdock Kenneth J, Natho
George JW. Creatine phosphokinase: a
spectrophotometric method with improved
sensitivity. American Journal of Clinical
Pathology, 1968; 50.1: 89-97.
Hou Xinwei, et al. Associations of amylin with
inflammatory markers and metabolic
syndrome in apparently healthy
Chinese. PLoS One, 2011; 6. 9: e24815.
Karras David J, Kane Diana L. Serum
markers in the emergency department
diagnosis of acute myocardial
infarction. Emergency medicine clinics of
North America, 2001; 19.2: 321-337.
Lee Wen-Ling, Lee Fa-Kung, Wang Peng-Hui.
Amylin, bariatric surgery, and type 2 diabetes
mellitus. Journal of the Chinese Medical
Association, 2021; 84.11: 983-984.
Mahjoob Golnoosh, et al. Circulating
microRNAs as predictive biomarkers of
coronary artery diseases in type 2 diabetes
patients. Journal of Clinical Laboratory
Analysis, 2022 ;36.5: e24380.
Majid A, Sayer S A. Protective effect of
phenolic extract of Cyperus rotundus
rhizomes on myocardial infarction
induced by isoproterenol in female rats.
In: IOP Conference Series: Materials
Science and Engineering. IOP Publishing,
; 012005.
Mcbride Patrick. Triglycerides and risk for
coronary artery disease, Current
atherosclerosis reports, 2008; 10.5: 386-390.
Mendis S, Thygesen K, Kuulasmaa K,
Giampaoli S, Mähönen M, NguBlackett K,
et al: World Health Organization definition
of myocardial infarction: 2008–09 revision,
Int J Epidemiol. 2011; 40(1): 139–46.
Puleo Peter R, et al. Use of a rapid assay of
subforms of creatine kinase MB to
diagnose or rule out acute myocardial
infarction. New England Journal of
Medicine, 1994; 331.9: 561-566.Raj Dominic, et al. Regulatory responses to
an oral D-glutamate load: formation of Dpyrrolidone carboxylic acid in
humans. American Journal of PhysiologyEndocrinology and Metabolism, 2001;
2: E214-E220.
Reinehr Thomas, et al. Amylin and its relation to
insulin and lipids in obese children before
and after weight loss. Obesity, 2007; 15.8:
-2011.
Tietz N W, Burtis C A, Ashwood E R,
Saunder W B. TextBook of Clinical
Chemistry. 3rd Ed, 1999; PP: 809–57.
Trinder Paul. Determination of glucose in
blood using glucose oxidase with an
alternative oxygen acceptor. Annals of
clinical Biochemistry, 1969; 6.1: 24-27.
Wang Xi-Ying, et al. The biomarkers for acute
myocardial infarction and heart
failure. BioMed research international, 2020.
Zhang Xiao-Xi, et al. Neuroendocrine
hormone amylin in diabetes. World
journal of diabetes, 2016; 7.9: 189.
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