The Relationship Between Homocysteine, Dopamine and Folic Acid in Serum of Patients with Cardiovascular Disease in Nassiria Governorate
Keywords:
Cardiovascular diseases, Dopamine, Homocysteine, FolateAbstract
Objectives: Cardiovascular diseases(CVDs) which include ischemic heart disease, stroke, heart failure, peripheral arterial disease, and several other cardiac and vascular illnesses, are the world's leading cause of mortality and significantly lower life expectancy. The research targeted at regulation of homocysteine metabolism has the potential to improve the quality of life and health span. The research also included measuring and evaluating dopamine and vitamin B9 for cardiovascular patients. Methods: This study was conducted at Nasiriya Heart Center ,Nasiriya General Hospital and Biochemistry Laboratory in the College of science University of Thi-Qar in the period between (October ,2022 to March, 2023) . In formed oral consent was taken for patients. The study included 88 men and women, 38control subjects and 50 patients their ages were between 40 – 70 years. The subjects were divided into two groups: 1. Control group: included (38) supposed approximately healthy subject,2. Patients group: included (50) patients with Heart disease. Excluded cases from this: Kidney diseases, Liver failure, Thyroid diseases Immunological diseases, Urinary tract infections, Acute joint diseases Pregnant women, Diabetes. Results : There was a significant increase in homocysteine concentration in the blood serum of the patients group compared to the control group. Significant decrease in the level of vitamin B9 and dopamine in the serum of patients compared to the control group. Conclusions: The study indicated a significant decrease in dopamine levels in cardiovascular patients, offset by an increase in homocysteine levels, which is considered a risk factor in cardiovascular patients. In addition, folic acid levels decreased in cardiovascular patients, and this contributed to the rise in homocysteine through the negative relationship between homocysteine and folic acid
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