The modification of Cowpea Mosaic Virus (CPMV) with Aspirin and Its application as Anti- Infectious Drugs
Keywords:
Aspirin, inflammatory disease, Viral nanoparticle.Abstract
Currently, Infectious diseases are of the most concern and threat to the entire world. They are caused by bacterial, fungal, parasitic and viral infections. Now days, nanotechnology-based drug delivery systems are in use to overcome these challenges. The current research focuses on the use of aspirin as an anti-inflammatory drug, both with and without conjugation to the outer surface of (CPMV) in order to enhance the efficacy of therapeutics and reduce or eliminate the drug resistance which is the biggest biological problem in the treatment of infectious diseases. Due to the resistance to commercially available medications, the particle used as an Aspirin (AS) carrier. When compared to free Aspirin, which has limited anti-infectious effect, the CPMV-AS conjugate, in which 160 molecules are covalently linked to the exterior surface amines of the viral nanoparticle (VNP), showed the strongest suppression against both gram-positive and gram-negative bacteria.
Downloads
References
J .Morley ,Proc. Roy. Soc. Med. ,(1977):70.
. P. Zimmermann, N. Curtis ,National Library of Medicine,
(11), 967,(2018).
G .Ortiz-Muñoz, B .Mallavia, A .Bins, M .Headley, M.F.
Krummel, M.R., Blood. 124(17), 2625 ,(2014).
M .Osthoff, J.A Sidler,. B Lakatos, R. Frei, M .Dangel, M
.Weisser, et al., Crit Care Med. 44,773, (2016).
. E. Strable , M.G. Finn,. ‘Chemical Modification of Viruses
and Virus-Like Particles’. In: Manchester, M.; Steinmetz,
NF., editors. Curr. Top. in Microbiol. Immunol. SpringerVerlag, Berlin, 1, (2009).
D.J. Evans, J. Mater. Chem. 363, 1070, (2010).
D.J. Evans , G.P Lomonossoff, ‘Applications of Plant
Viruses in Bionanotechnology’. In: Palmer, K.; Gleba, Y.,
editors. Curr. Top. in Microbiol. Immunol. SpringerVerlag; Berlin: (2012). in press.
F.R .Brennan, T.D. Jones, W.D .Hamilto, . Mol.
Biotechnol,17, 15,(2001).
J.Johnson, , T. Lin, G. Lomonossoff, Annu. Rev. Phytopathol.
, 67,(1997).
G.P. Lomonossoff, J.E .Johnson, Prog. Biophys. Mol. Biol.
,107, (1991).
Q.Wang, , T.Lin, L.Tang, J.Johnson, M .Finn, Angew. Chem.
Int. Ed.,41, 459, (2002).
R. A. K. Al-Refai’a, IJDDT, 9 (3), 491, (2019).
R. A.K. Al- Refai’a , PhD, Hull University,( 2008).
C.H. Teh, W.A. Nazni, H.L. Lee, A .Fairuz, S.B Tan, S.A.
Mohd. Lucilia cuprina. Med Vet Entomol. 27(4),414, (2013).
Downloads
Published
Issue
Section
License
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
