Topical Formulation and in-Vitro Assessment of Moxifloxacin Hydrochloride Emulgel
Keywords:
MOXF HCL, Emulgel, Cellulose derivative polymersAbstract
Moxifloxacin HCL (MOXF HCL) was formulated as an emulgel dosage form in eight formulas using five main gel bases, carboxymethyl cellulose, hydroxypropyl methylcellulose, sodium alginate, sodium carboxy methyl cellulose, and a combination of hydroxypropyl methylcellulose and sodium alginate. The study revealed that the best emulgel base with accepted physical properties was CMC 2 %(w/w) in combined span 20 and tween 20 as surfactants compared with other cellulose derivative polymers, which gave us 97.85% of drug release. In contrast, HPMC gave us 76.5%, NaCMC gave us 57.83%, and Sod. Alginate gave us 64.92%, and HPMC/sod.alginate gave us 67.64%. Moreover, the Moxifloxacin HCL release from the selected formula in phosphate buffer pH 5.5 was increased as a result of growing surfactants used while increasing the liquid paraffin as an oil phase resulted in a decrease of drug release. On the other hand, the kinetic analysis of the amount of drug release from all Emulgel bases used showed mostly obeyed the Higuchi model.
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