Analysis of serum iron and haemoglobin in Oral Submucous Fibrosis
Keywords:
precancerous, oral submucous fibrosis, haemoglobin, iron, inflammation, collagen depositionAbstract
Background: Oral submucous fibrosis is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. It is precancerous disorder and transforms into a malignant tumour in 1.5-15% of all cases. OSMF causes significant haematological abnormalities resulting in anaemia and a decrease in serum iron levels.
Aim: The aim of this study was to estimate the haemoglobin and serum iron levels among patients with oral submucous fibrosis and to compare the values with healthy subjects.
Materials and Methods: In this hospital-based study 40 diagnosed patients of OSMF and 20 healthy individuals were included, and the values of haemoglobin and serum iron levels were estimated using Sahli’s and Ferrene methods.
Results: OSMF patients showed significantly lower levels of haemoglobin and serum iron when compared with the healthy subjects.
Conclusion: The findings of the study emphasize on the assessment of haemoglobin and serum iron for patients with oral submucous fibrosis. Also, iron therapy should be instituted concomitantly with the initial diagnosis which helps to cease the further progression of the condition. Further extensive studies are indicated to understand the correlation between OSMF and iron deficiency.
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